Halvtidsseminarier Halvtidskontroll Hemantha Mallapura
Titel: Automated microfluidic-based production of PET radioligands for clinical and preclinical use
Huvudhandledare
Forskningsspecialist Sangram Nag, Institutionen för klinisk neurovetenskap Karolinska Institutet
Bihandledare
Professor Christer Halldin, Institutionen för klinisk neurovetenskap, Karolinska Institutet
Professor Bengt Långström, Institutionen för kemi, Uppsala universitet
Ludovic Le Meunier
Halvtidsnämnd
Professor Nicole Pamme, Institutionen för material- och miljökemi, Stockholm University,
Dr. Johnny Vercouillie, School of Pharmacie, University of Tours
Dr. Philip Miller, Department of Chemistry, Imperial College London
Kort beskrivning
This project aims to produce clinically applicable Positron Emission Tomography (PET) radioligands with carbon-11 (11C), fluorine-18 (18F) and gallium-68 (68Ga) isotopes using a microfluidic cassette-based iMiDEV™ automated radiosynthesizer for clinical and preclinical applications. In addition, developing and optimizing experimental conditions for [11C]methyl iodide synthesis ([11C]CH3I) using a non-thermal plasma method and [11C]CH3I is one of the most used methylating agents in 11C radiochemistry.