Föreläsningar och seminarier OnkPat Friday Seminar – Fourth-Generation EGFR-TKIs: From Rational Design to Conformational Dynamics of Mutant Kinase Domains

Värd: Domenico Scaramozzino, institutionen för onkologi-patologi. 

Läs Cristina Minnellis bio på den engelska sidan.

Publikationer

Targeting the lipid membrane to prevent viral entry: the case of a C18-alkylated EGCG compound.
Minnelli C, Caucci S, Galeazzi R, Laudadio E, Romagnoli E, Frontini A, Rao L, Notarstefano V, Armeni T, Romaldi B, Menzo S, Mobbili G
Chem Biol Interact 2026 Feb;430():111971

FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism.
Romagnoli E, Laudadio E, Mobbili G, Sorci L, Birarda G, Piccirilli F, Vaccari L, Vondracek H, Romaldi B, Marcaccio M, Storici P, Semrau M, Galeazzi R, Toma A, Aglieri V, Stipa P, Armeni T, Minnelli C
Int J Biol Macromol 2025 Aug;319(Pt 2):145453

Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design.
Laudadio E, Piccirilli F, Vondracek H, Mobbili G, Semrau MS, Storici P, Galeazzi R, Romagnoli E, Sorci L, Toma A, Aglieri V, Birarda G, Minnelli C
Phys Chem Chem Phys 2024 Sep;26(35):22853-22857

Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC.
Laudadio E, Mangano L, Minnelli C
ACS Chem Biol 2024 Apr;19(4):839-854

Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns.
Laudadio E, Mobbili G, Sorci L, Galeazzi R, Minnelli C
J Biomol Struct Dyn 2023 ;41(14):6492-6501

Insights into PLGA-encapsulated epigallocatechin 3-gallate nanoparticles as a new potential biomedical system: A computational and experimental approach.
Minnelli C, Stipa P, Sabbatini S, Mengucci P, Mobbili G, Galeazzi R, Armeni T, Romaldi B, Celli A, Laudadio E
European Polymer Journal 2023, 182, 111723.

Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC.
Cristina M, Emiliano L, Leonardo S, Giulia S, Roberta G, Adolfo A, Marta SS, Paola S, Samuele R, Pierluigi S, Massimo M, Giovanna M
Bioorg Chem 2022 Dec;129():106219

Tuning curvature and phase behavior of monoolein bilayers by epigallocatechin-3-gallate: Structural insight and cytotoxicity.
Minnelli C, Moretti P, Laudadio E, Gerelli Y, Pigozzo A, Armeni T, Galeazzi R, Mariani P, Mobbili G
Colloids Surf B Biointerfaces 2022 Jan;209(Pt 1):112171

Influence of a lipophilic edaravone on physical state and activity of antioxidant liposomes: An experimental and in silico study.
Minnelli C, Laudadio E, Fiorini R, Galeazzi R, Armeni T, Stipa P, Rusciano D, Mobbili G
Colloids Surf B Biointerfaces 2022 Feb;210():112217

Selective induction of apoptosis in MCF7 cancer-cell by targeted liposomes functionalised with mannose-6-phosphate.
Minnelli C, Cianfruglia L, Laudadio E, Galeazzi R, Pisani M, Crucianelli E, Bizzaro D, Armeni T, Mobbili G
J Drug Target 2018 Mar;26(3):242-251