Publicerad: 2022-09-23 14:27 | Uppdaterad: 2022-09-23 14:27

The synovial microenvironment directly influences the formation and maintenance of articular cartilage

ola nilsson research group
Ola Nilsson with research group

The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation

Articular cartilage is essential to joint function, but the fundamental mechanisms that control its differentiation and protect it from endochondral bone formation has not been elucidated. In the current issue of NPJ Regenerative Medicine, associate professor Ola Nilsson and co-authors at the department of women’s and children’s health reveal a novel mechanism by which synoviocytes produce factors that directly regulate chondrocyte differentiation, inhibiting chondrocyte hypertrophy and endochondral bone formation, and promoting articular cartilage formation. This mechanism has important implications for articular cartilage development, maintenance, and regeneration and thus applicable to the understanding of joint development as well as the pathogenic mechanisms underlying degenerative joint diseases such as osteoarthritis and rheumatoid arthritis. These finding also points towards a new help the development of efficient articular cartilage tissue engineering methods.

https://www.nature.com/articles/s41536-022-00247-2

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