Föreläsningar och seminarier Seminarium: "The needs of a synapse - how secretory lysosomes serve synaptic proteostasis"

Name: Seminarium: "The needs of a synapse - how secretory lysosomes serve synaptic proteostasis"
Start: 2025-01-17T13:30:00+0100
End: 2025-01-17T14:30:00+0100
Location: Campus Solna

2025-01-17 13:30 - 14:30 Add to iCal

Campus Solna Campus Solna, Nils Ringertz, Biomedicum våning 3, Solnavägen 9, Solna

Välkommen till ett seminarium med Dr Katarzyna Grochowska från Center for Molecular Neurobiology Hamburg, Tyskland.

Bild:

Rubrik:

Katarzyna Grochowska Photo: N/A

Titel

"The needs of a synapse - how secretory lysosomes serve synaptic proteostasis"

Talare

Dr Grochowska är postdoc i Dr Michael R. Kreutzs labb på Center for Molecular Neurobiology Hamburg, Tyskland.

Ett urval av publikationer

Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Woo MS, Friese MA, Lohr C, Grochowska KM. (2024). Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling. Glia, 72(8):1451-1468. doi: 10.1002/glia.24539.

Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR. (2023). Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal. Cell Rep., 42(8):112998. doi: 10.1016/j.celrep.2023.112998

Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski M, Goldschmidt J, Friese MA, Rossner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR. (2023). Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. EMBO J., 42(4):e112453. doi: 10.15252/embj.2022112453.

Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. (2017). Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep., 18(6):962-981. doi: 10.15252/embr.201643519.

Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D'Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. (2016). A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics, 12(3):e1005907. doi: 10.1371/journal.pgen.1005907.