Föreläsningar och seminarier Pediatric Oncology seminar

2022-04-07 12:00 Add to iCal
Karolinska Universitetssjukhuset, Solna Online/Plan 12, F, NKS Barn (outside Barnonkologiska slutenvårdsavdelningen)

Lilly Velentza, PhD student, Sävendahl Lab and Clary Georgantzi, MD/PhD, pediatric oncologist

Lilly Velentza, PhD student, Sävendahl Lab

Title: Investigating the effects of Bcl-2 inhibition with venetoclax on longitudinal bone growth 

Summary: Bone-related toxicities represent a common complication during treatment for childhood cancer. Venetoclax is a Bcl-2 inhibitor which has been approved for adult patients and is currently under investigation in pediatric cancer clinical trials. However, Bcl-2 pathway plays also a crucial role during development and bone growth. In the present project, we aimed to investigate any negative off-target effects of venetoclax on the bone tissue by applying different experimental models, including an in vivo neuroblastoma model. 


Clary Georgantzi, MD/PhD, pediatric oncologist

Title: A success story: treatment with an ALK inhibitor

Summary: A case report about a patient with HR NBL with an ALK mutation who was treated with an ALK inhibitor. 


Moderator: Ninib Baryawno