Föreläsningar och seminarier Pediatric Oncology seminar
Research Seminars Childhood Cancer Research Unit presents:
Tomas Bexelius, (MD, PhD), Karolinska Institutet
Title: Experience of a tailored molecular profiling programme from children for targeted treatment as a paediatric drug development fellow in the UK.
Summary: Precision medicine efforts are undergoing transition from research to becoming a part of clinical practice. Here a study from England is presented involving Primary refractory or relapsed cancer patients using a tailored childhood cancer Gene panel. For more information please See attached file.
Adena Pepich, PhD student, Wickström group
Title: Targeting neuritogenesis genes for improved therapies in and better understanding of neuroblastoma.
Summary: Genes underlying important functions in embryogenesis are frequently dysregulated or oncogenic in pediatric cancers. We found previously that neuroblastoma patients often bear genetic aberrations in genes related to neuritogenesis; genes that are associated with neural crest migration and differentiation. In our whole-genome and whole-exome sequencing we uncovered that 27.5% of neuroblastoma patients had somatic protein changing mutations in genes associated with Rho/Rac signaling and roughly 10% of patients had somatic mutations in teneurin (TENM) receptor family proteins. Our aim has been to identify and evaluate these novel therapeutic targets involved in neuritogenesis for better understanding of neuroblastoma disease progression and therapy resistance.
Moderator: Shahrzad Shirazi Fard