Föreläsningar och seminarier Pediatric Oncology seminar
Pesentations from the Childhood Cancer Research Unit with Quinty Wellema and Ioana Gavriluc
Hala Habash, student, Henter-Herold Lab
Title: Attempting to define an animal model for histiocytosis
Summary: Due to the absence of a relevant in vivo model, research into Langerhans Cell Histiocytosis (LCH) and its treatment has been difficult. In this study, we propose a viral porcine disease as a possible animal model for LCH pre-clinical research
Quinty Wellema, Master student, Wickström Lab
Title: Novel combinational approaches for neuroblastoma therapy – discovery of combination partners for the ROCK2-specific inhibitor KD-025
Summary: ROCK2 has been suggested to play a role in drug resistance. In order to determine beneficial drug combination partners for the ROCK2-specific inhibitor KD-025 we have performed a combinational screening, using experimental and approved cancer drugs, in three neuroblastoma cell lines. One of the identified hits was the dual ERK/AKT inhibitor TIC10 and follow-up studies confirmed the efficacy and synergy of the drug combination. Furthermore, we are currently evaluating the mechanisms underlying the observed synergy.