Föreläsningar och seminarier OnkPat Friday Seminar: In vivo CRISPR engineering to reprogram human T cells
Välkommen till OnkPat Friday Seminar, den här gången med William Nyberg, biträdande lektor vid institutionen för medicin, Huddinge, Karolinska Institutet.
Värd: Kasper Karlsson, institutionen för onkologi-patologi
Du kan läsa mer om seminariet på den engelska sidan.
Relevanta publikationer
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.
Nyberg WA, Wang CH, Ark J, Liu C, Clouden S, Qualls A, Caryotakis S, Wells E, Simon K, Garza C, Bernard PL, Lopez-Ichikawa M, Li Z, Seo J, Kimmerly GR, Muldoon JJ, Chen PA, Li M, Liang HE, Kersten K, Rosales A, Kuhn N, Ye CJ, Gardner JM, Molofsky A, Ricardo-Gonzalez RR, Asokan A, Eyquem J
Immunity 2025 Feb;58(2):499-512.e7
An evolved AAV variant enables efficient genetic engineering of murine T cells.
Nyberg WA, Ark J, To A, Clouden S, Reeder G, Muldoon JJ, Chung JY, Xie WH, Allain V, Steinhart Z, Chang C, Talbot A, Kim S, Rosales A, Havlik LP, Pimentel H, Asokan A, Eyquem J
Cell 2023 Jan;186(2):446-460.e19
RASA2 ablation in T cells boosts antigen sensitivity and long-term function.
Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A
Nature 2022 Sep;609(7925):174-182
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci.
Chang CR, Vykunta VS, Lee JHJ, Li K, Kochendoerfer C, Muldoon JJ, Wang CH, Mazumder T, Sun Y, Goodman DB, Nyberg WA, Liu C, Allain V, Rothrock A, Ye CJ, Marson A, Shy BR, Eyquem J
Nat Biotechnol 2025 Feb;():