Föreläsningar och seminarier Forskningsseminarium vid avdelningen för Ögon & Syn - James Tribble

2023-03-14 12:00 Add to iCal
S:t Eriks Ögonsjukhus Eye Center of Excellence, Aulan plan -1, St Eriks Ögonsjukhus

Avdelningen för Ögon och Syn välkomnar dig till ett forskningsseminarium med forskargrupp Pete Williams som värd. Talare för seminariet är James Tribble.

James Tribble Foto: Pete Williams

Titel: Preventing retinal homocysteine dysregulation protects against retinal ganglion cell death.

Talare: James Tribble is Assistant Professor in Pete Williams group. James’ research is focused on neuroinflammation and metabolism. James trained in Cardiff University beforejoining the Williams group as a postdoc in 2018. James will present his latest work as a postdoc under Pete Williams.

Metabolic dysfunction has emerged as a key early component of glaucoma. We identify elevated retinalhomocysteine as a strong early metabolomic signature, with early-and sustained-dysregulation of genesinvolved in homocysteine’s wider metabolism. We assessed whether elevated homocysteine contributed toretinal ganglion cell degeneration in animal models and in large-scale human data.Metabolism of homocysteine requires vitamin B6 and B12 as essential cofactors, and folic acid (B9) and cholineare essential precursors. We explored the possibility of local retinal deficiency in these vitamins, and thepotential of supplementing these in the diet to protect retinal ganglion cells from degeneration in glaucoma.

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14 mars kl 12.00, Eye Center of Excellence, Aulan plan -1, S:t Eriks Ögonsjukhus. Lunchsmörgås serveras från kl 11.50.


Maria Persson Administratör