Föreläsningar och seminarier Discover the combinatorial power of genetics and epigenetics at single-base resolution from limited DNA

2023-11-29 13:00 - 14:00 Add to iCal
Campus Solna CMM Lecture Hall (Visionsgatan 18, entréplan) och zoom

Maja Jagodics forskargrupp välkomnar dig till detta intressanta seminarium om teknikutveckling. Ämnet för seminariet är inom området genetik och epigenetik, med talare Dan Brudzewsky, doktorand och forskare, biomodal UK.

Dan Brudzewsky har en doktorsexamen i medicinsk genetik från Köpenhamns universitet och postdoktoral utbildning vid Helsingfors universitet, Imperial College London och University of Coimbra. Han har en bred erfarenhet inom forskningsområden som onkologi, immunologi, immunonkologi och oftalmologi.  Under de senaste sju åren har han arbetat inom bioteknik med att hjälpa laboratorier att anpassa ny teknik inom genomik, till exempel biomodals multiomiklösning Duet.

Titel: "Discover the combinatorial power of genetics and epigenetics at single-base resolution from limited DNA"

(observera att seminariet genomförs på engelska).
 

Abstract

DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology in health and disease. The interaction of genetics with the epigenome plays a causal role in cell fate, ageing, and disease development.

We introduce duet multiomics solution, a single base-resolution sequencing methodology that sequences complete genetics and cytosine modifications in a single workflow, enabling the identification of genetic variants and quantification of modified cytosine levels in a single experiment, at high accuracy for both genetics and epigenetics. This method is compatible with low quantities of input material, enabling the measurement of genetics and methylation in cfDNA, increasing the information available to identify traces of disease using liquid biopsy. The phased nature of the technology, whereby genetic and epigenetic information is available simultaneously on the same DNA fragment, enables the study of genetic and epigenetic co-variation such as in allele-specific methylation (ASM), whereby differential methylation patterns are observed between heterozygous variants. This technology enables simultaneous multiomic information to be gathered unlike ever before and will help to understand the dynamism of biology throughout health and disease.

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