Föreläsningar och seminarier Cognitive Neuroscience Club med Duncan Astle: "A transdiagnostic approach to neurodevelopment"

"A transdiagnostic approach to neurodevelopment"

Föreläsare/talare

Dr Duncan Astle, Group Leader, MRC Cognition and Brain Sciences Unit, University of Cambridge, Storbritannien

Macroscopic brain organisation emerges early in life, even prenatally, and continues through adolescence and into early adulthood.

The emergence and continual refinement of large-scale brain networks, connecting neuronal populations across anatomical distance, allows for increasing functional integration and specialisation. This process is thought crucial for the emergence of complex cognitive processes. But how and why is this process so diverse?

We used structural neuroimaging collected from 479 children who are members of an intentionally diverse cohort of struggling learners to explore how different features of macroscopic brain organisation are associated with diverse cognitive trajectories. We used diffusion-weighted imaging (DWI) to construct whole-brain white-matter connectomes. A simulated attack on each child's connectome revealed that some brain networks were strongly organized around highly connected ‘hubs’. The more children’s brains were critically dependent on hubs, the better their cognitive skills. Conversely, having poorly integrated hubs was a very strong risk factor for cognitive and learning difficulties across the sample.

We subsequently developed a computational framework, using generative network modelling (GNM), to model the emergence of this kind of connectome organisation. Relatively subtle changes within the wiring rules of this computational framework give rise to differential developmental trajectories, because of small biases in the preferential wiring properties of different nodes within the network.

Finally, we were able to use this GNM to identify the molecular and cellular processes that govern these different growth patterns. Finally we explore how these preferential wiring mechanisms might originate at a cellular level by modelling the formation of neural networks in vivo.