Titel

"Functional interdependencies of noncoding and protein-coding transcriptomes in liver cancer"

Ordförande

Edmund Loh

Handledare

Claudia Kutter

Titel

"Reprogrammed human stem cells as a model for medulloblastoma development"

Ordförande

Sonia Lain

Handledare

Margareta Wilhelm

Titel

Yerma Pareja Sanchez: "Mechanisms of transcriptional memory and its impact on anti-tumor drug resistance"

Yujie Zhang: "Study of eukaryotic translation dynamics and its impact on cell heterogeneity"

Ordförande

Susanne Schlisio

Handledare

Vicente Pelechano Garcia

Titel

"Nanoscale Functional Materials for Biomedical Diagnostics"

Ordförande

Jonathan Coquet

Handledare

Georgios Sotiriou

Moderatorer

Ylva Elin-Nowak, APC och Gunnar Nilsson, sektionen för allmänmedicin och primärvård.

Medverkande

Helena Salminen, sektionschef, sektionen för allmänmedicin och primärvård.

Jan Hasselström, verksamhetschef APC.

Mika Gissler och Johan Ärnlöv berättar om sin forskning.

Zoom

Delta via Zoom: https://ki-se.zoom.us/j/69737813155

Varmt välkomna - ingen föranmälan krävs!

Kontakt

The benefits of life-long exercise

Talare: Stefan Rietzner, FyFa, Sundberg lab.

Structural Switch of microRNA 34a Enhances mRNA targeting

Talare: Katja Petzold, MBB, Petzold lab.

Human high-grade glioma tumoroids respond differently to drugs in 2D versus 3D cultures and bioprinting

Talare: Jose Maria Oliva Montero, Neuro, Hermanson lab.

Kommande seminarier 

Den 2 juni.

Mathias Lemberger, doktorand, enheten för ortodonti

Projekttitel: Evaluation of the reconstructed alveolar cleft in children born with UCLP

Huvudhandledare: Agneta Karsten

Seminarievärd: Agneta Karsten

Seminariet hålls på engelska.

Zoom

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Meeting ID: 698 2049 1693
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Sui Huang, MD, PhD, obtained his doctorates in medicine and molecular biology at the University of Zurich in 1995 working on interferons.  After postdoctoral training in cancer biology, he became faculty at Harvard Medical School in Boston, where he studied cell fate decisions. At the University of Calgary he worked alongside Stuart Kauffman on gene regulatory networks and cancer differentiation therapy (=exiting the cancer attractor), before joining the Institute for Systems Biology in Seattle in 2011. Sui Huang demonstrated that cell types are attractor states in high-dimensional gene expression space and uncovered that cell state instability precedes cell fate decisions. His current laboratory at ISB combines single-cell omics technologies and theory of non-linear dynamical systems to better the fundamental inevitability of tumor progression.

Abstract
Cancer appears to be universal in complex living organisms.  Therefore, it may be a necessary manifestation of their robustness – which is epitomized by regenerative capacity. In this talk I will review the theory of gene regulayory networks, concepts of the cell attractor, multistability, and the “rugged epigenetic landscape”, as well as the evolution of regeneration -- leading to stress-indcued stemness. From this follows that cytotoxic stress imparted by treatment itself will either kill the cancer cell or induce stemness, thereby planting the seed for recurrence.  Thus, tumors exhibit Nietzsche’s principle of “What does not kill me makes me stronger” – perhaps a manifestation of instability and (non-genetic) bifurcation dynamics. I will demonstrate the practical consequences for treatment (which is poised to “backfire”) – supported by the latest single-cell transcriptomics data.

Programmet kommer att innehålla presentationer följt av Q&A.

Anmälan

Registrera dig för seminariet.

Var snäll och anmäl dig senast den 18:e maj 2021.

Arrangörer

Seminariet anordnas gemensamt av studentrepresentanterna för GlobeLife, både från Karolinska Institutet och Uppsala Universitet.

Varmt välkommen,

Hager Seleh KI, Leo Gkekos KI, Adama Awasom-Fru UU & Lina Wallberg UU.

"BioNut Seminar Series" är en ny seminarieserie där de olika gruppledarna vid Institutionen för biovetenskaper och näringslära bjuder in till och är värd för ett seminarium på utvalda torsdagar under hela året. 

Just nu hålls dessa seminarier enbart över Zoom.

Välkomna!